NSAID Induced Stevens Johnson Syndrome or Tumor Epidermal Necrolysis

Abstract: Non-steroidal Anti-inflammatory Drugs (NSAIDs) are the drugs which commonly prescribed and consumed by worldwide. NSAIDs several having high risk of inducing SJS or TEN. TEN cutaneous reactions involves in detachment mucosal skin membrane. Female were more affected than male. Major cause genetic (HLA –A HLA- B), drugs, infection (mycoplasma pneumonia herpes simplex virus). The exact pathogenic mechanism uncertain. People who 40 years mostly Due to rarity these diseases, sufficient evidence is still lacking support best choice treatment for patients with Most like antibiotics, anticonvulsant causes Diagnostic test prick test, PCR serology was used diagnose Patients treated various immunomodulators (IVIG), Cyclosporine, systemic corticoSteroidals, TNF inhibitors, Plasmapheresis addition supportive care. Keywords: NSAIDs, Steven Johnson Syndrome, Tumor epidermal necrolysis, Drug reactions, Adverse reaction.